Synerase is a unique proteolytic enzyme combination with diverse clinical benefits, showing efficacy both for systemic inflammation as well as digestive function. This multienzyme formulation contains digestive enzymes with physiological influences extending well beyond protein digestion. This is in part due to the increase in food allergies as a result of incomplete protein digestion, which may be responsible for more systemic effects.1 Beyond protein digestion, bromelain has been shown to reduce blood viscosity, prevent aggregation of blood platelets, reduce levels of prostaglandin E2 and thromboxane A2, and in an open study it improved symptoms of mild, acute knee pain.2,3,4 Bromelain also has demonstrated immunomodulatory effects in a variety of models, preventing neutrophil migration in response to IL-8 during inflammation, and inhibiting pro-inflammatory chemokine and cytokine secretion.5,6,7