Bioclinic Naturals EstroVantage EM 90 Veg Capsules :

In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17ß-estradiol. In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16a-hydroxyestrone (16a-OHE1). Both 16a-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16a-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.2 As such, an increased ratio 2-OHE:16a-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.3 Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events. Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5 It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.6

Benefits :

IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.7

In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients8

Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo and in vitro9

Silymarin can down-regulate gene products involved in the proliferation of tumour cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)10

Curcumin inhibits human breast cancer cell growth by mediating certain signalling cascades including the modulation of the NF-?B signalling pathway11

Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression12

Standardized extracts

Ingredients :

Each Capsule Contains:

Calcium D-Glucarate (d-Glucaric Acid Calcium Salt)........................75 mg

Indole-3-Carbinol (3-Hydroxymethylindole)...................................75 mg

Green Tea Extract (Camellia sinensis) (leaf)

(80% Catechins, 45% EGCg <1% Caffeine)..................................50 mg

Tomato Extract (Lycopersicon esculentum)

(fruit) (5% Lycopene)................................................................50 mg

Broccoli Powder (Brassica oleracea var. italica)

(aerial) (0.36% Sulforaphane)..................................................27.5 mg

Turmeric Extract (Curcuma longa) (rhizome)

(95% Curcuminoids)...................................................................25 mg

Milk Thistle Extract (Silybum marianum)

(seed) (60% Silymarin)...............................................................25 mg

DIM (3,3’-Diindolylmethane)........................................................25 mg

Rosemary Extract (Rosmarinus officinalis) (leaf)...........................12.5 mg

Non-medicinal Ingredients :

Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant), silica.

Allergens :

Contains no artificial preservatives, colours or sweeteners and no dairy, wheat or yeast. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Recommended Adult Dose :

3 capsules per day taken with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks. Keep out of reach of children.