Digest-ProGD® HP is a high potency proprietary enzyme blend, providing fungal proteases derived from Aspergillus oryzae, bacterial protease derived from Bacillus subtilis, as well as comprehensive carbohydrate digestive support from papain, bromelain, and fungal digestive enzymes. Aspergillus oryzae extracts are rich in prolyl endopeptidases as well as dipeptidyl peptidase IV (DPP-IV) – a multifunctional serine protease which targets proline containing peptides, such as those found in both gliadin and casein, both proteolytically resistant proteins.1-3
Indeed, protease activity from Aspergillus oryzae targets the proline-rich 33-mer of gliadin, perhaps the most immunotoxic peptide derived from gliadin.4 The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often due to inadvertent gluten exposure, even for those on a gluten free diet.5 Supplementation with protease from Aspergillus oryzae has also been linked to a bifidogenic effect in animals, suggesting a potential probiotic effect.6
In addition to fungal and bacterial proteases, Digest-ProGD® HP provides alpha-amylase, cellulose, and hemicellulose activity for comprehensive carbohydrate digestion support.
|Each Vegetarian Capsule Contains:|
|Proprietary Enzyme Blend||295 mg|
|Fungal Protease (Aspergillus flavus var. oryzae) (whole)||153.35 mg (690 FCC SAP)|
|Bacterial Protease (Bacillus subtilis) (whole)||75 mg (75,000 FCC PC)|
|Fungal Protease (Aspergillus flavus var. oryzae) (whole)||24.36 mg (6,700 FCC HUT)|
|Alpha-Amylase (Aspergillus flavus var. oryzae) (whole)||18.67 mg (2,800 FCC DU)|
|Bromelain (Ananas comosus var. comosus) (stem)||9.55 mg (315,000 FCC PU)|
|Papain (Carica papaya) (fruit)||7.5 mg (315,000 FCC PU)|
|Cellulase (Trichoderma longibrachiatum) (whole)||3.78 mg (680 FCC CU)|
|Hemicellulase (Aspergillus niger) (whole)||2.34 mg (1,875 FCC HCU)|
|FCC: Food Chemical Codex, SAP: Spectrophotometric Acid Protease Unit, PC: Protease Unit, HUT: Hemoglobin Unit on the Tyrosine Basis, DU: Dextrinizing Unit, PU: Papain Unit, CU: Cellulase Unit, HCU: Hemicellulase Unit|
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant).
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.