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Rationale & Viability of revised Biotone EFA Formulation
Biotone EFA has many therapeutic indications as supported by various forms of research as noted below. Seroyal is continuously researching each ingredient in each one of our formulations against the most recent scientific evidence. As we propose these findings to our expert committee we believe it is sometimes necessary after laborious analysis of the research and our client?s expectations, to optimize our formulations to remain as a leader in the natural pharmaceutical industry.
Changes on the Biotone EFA label:
The phytosterol amount has been increased from 16 mg/capsule to 112 mg/capsule based on recent evidence of the benefits of phytosterols on cardiovascular health and cholesterol reduction.
Along with octacosanol, we have added hexacosanol, tetracosanol, triacontanol and dotriacontanol. All of these components are included under policosanol, which has been found to have positive effects on cardiovascular health and cholesterol reduction.
Cardiovascular disease (CVD), including stroke, coronary occlusion, ischemic heart disease (IHD), atherosclerosis heart disease, vascular and coronary thrombosis, is the leading cause of death in most western societies. The factors most consistently associated with an increase in the incidence of CVD include hypertension, hypercholesterolemia, and cigarette smoking. Other modifiable risk factors include obesity, lack of exercise, hypertriglyceridemia and low high-density lipoprotein-cholesterol (HDL-C) levels (Patch et al, 2006).
The clinical manifestations of CVD are chronic arterial obstructions or acute arterial occlusions in various territories, which ultimately lead to the condition where there is an inadequate supply of blood to the heart muscle, brain or visceral limbs leading to ischemia in severe cases, myocardial infarction (Patch et al, 2006).
High blood cholesterol level (especially LDL cholesterol) is a risk factor for coronary heart disease (CHD). Oxidation of excess LDL cholesterol leads to arterial wall plaque build up, which then restricts blood flow and increased risk of coronary heart disease and stroke.
Biotone EFA is a unique combination of rice bran, soybean and wheat germ oils specifically formulated to support and regulate hormonal function. Rice bran and wheat germ oils are high in octacosanol, fatty acids, phytosterols, and in ketosteroids, anabolic growth agents, and lipotropic factors. Octacosanol, found in wheat and in rice oil fractions, improves heart functions, increases vitality and endurance, prevents muscle spasms, and duplicates the biological effects of sex hormones and ketosteroids without the side-effects associated with hormone therapy.
How are Essential Fatty Acids (EFAs) broken down in the body? Does
it require much work from the liver?
EFAs are broken down in the gut (hydrolyzed) and the individual fatty acids are absorbed by the enterocytes lining the GI tract. The enterocytes assemble the fatty acids and glycerol into triglycerides.The triglycerides and other fat soluble nutrients are collected and assembled into chylomicrons, which are absorbed by the lacteals (lymphatic vessels of the small intestines). The chylomicrons flow with the lymph into the blood and reaches every tissue in the body. In the tissues the triglycerides are absorbed in a similar way as triglycerides are absorbed by the enterocytes. In the tissues the fatty acids can be metabolized into for example local hormones.
The hydrolization process in the gut requires lipase secreted by the pancreas and bile synthesized in the liver and secreted from the gallbladder.